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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2011-4-13
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pubmed:abstractText |
Central nervous system (CNS) atypical teratoid/rhabdoid tumors (AT/RT) are aggressive tumors usually diagnosed in young children and characterized by SMARCB1 (INI1, hSNF5) gene abnormalities. Despite initial chemo-radiation responsiveness, most children die of progressive disease (PD). Little data regarding familial AT/RT clinical course exist. This study described and compared familial (F) versus sporadic (S) AT/RT and elucidated SMARCB1 mutations and inheritance patterns.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1545-5017
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Wiley-Liss, Inc.
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1026-31
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pubmed:dateRevised |
2011-11-8
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pubmed:meshHeading |
pubmed-meshheading:20848638-Central Nervous System Neoplasms,
pubmed-meshheading:20848638-Child, Preschool,
pubmed-meshheading:20848638-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:20848638-DNA-Binding Proteins,
pubmed-meshheading:20848638-Female,
pubmed-meshheading:20848638-Genetic Predisposition to Disease,
pubmed-meshheading:20848638-Germ-Line Mutation,
pubmed-meshheading:20848638-Humans,
pubmed-meshheading:20848638-Infant,
pubmed-meshheading:20848638-Male,
pubmed-meshheading:20848638-Pedigree,
pubmed-meshheading:20848638-Retrospective Studies,
pubmed-meshheading:20848638-Rhabdoid Tumor,
pubmed-meshheading:20848638-Survival Rate,
pubmed-meshheading:20848638-Teratoma,
pubmed-meshheading:20848638-Transcription Factors,
pubmed-meshheading:20848638-Treatment Outcome
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pubmed:year |
2011
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pubmed:articleTitle |
Clinicopathologic comparison of familial versus sporadic atypical teratoid/rhabdoid tumors (AT/RT) of the central nervous system.
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pubmed:affiliation |
Division of Hematology-Oncology, Department of Pediatrics, University of Utah School of Medicine and Primary Children's Medical Center, Salt Lake City, Utah, USA. carol.bruggers@imail.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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