Linked Life Data

20848589

Source:http://linkedlifedata.com/resource/pubmed/id/20848589

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2011-6-28
pubmed:abstractText
Searching for efficacious and safe agents for the chemoprevention and therapy of prostate cancer has become the top priority of research. The objective of this study was to determine the effects of a group of tanshinones from a Chinese herb Salvia Miltiorrhiza, cryptotanshinone (CT), tanshinone IIA (T2A) and tanshinone I (T1) on prostate cancer. The in vitro studies showed that these tanshinones inhibited the growth of human prostate cancer cell lines in a dose-dependent manner via cell cycle arrest and apoptosis induction. Among three compounds, T1 had the most potent activity with IC(50) s around 3-6 ?M. On the other hand, tanshinones had much less adverse effects on the growth of normal prostate epithelial cells. The epigenetic pathway focused array assay identified Aurora A kinase as a possible target of tanshinone actions. The expression of Aurora A was overexpressed in prostate cancer cell lines. Moreover, knockdown of Aurora A in prostate cancer cells significantly decreased cell growth. Tanshinones significantly downregulated the Aurora A expression, suggesting Aurora A may be a functional target of tanshinones. Tanshinones, especially T1, also showed potent anti-angiogenesis activity in vitro and in vivo. Furthermore, T1 inhibited the growth of DU145 prostate tumor in mice associated with induction of apoptosis, decrease of proliferation, inhibition of angiogenesis and downregulation of Aurora A, whereas it did not alter food intake or body weight. Our results support that T1 may be an efficacious and safe chemopreventive or therapeutic agent against prostate cancer progression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1097-0215
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 UICC.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1042-52
pubmed:dateRevised
2011-10-20
pubmed:meshHeading
pubmed-meshheading:20848589-Animals, pubmed-meshheading:20848589-Antineoplastic Agents, Phytogenic, pubmed-meshheading:20848589-Apoptosis, pubmed-meshheading:20848589-Blotting, Western, pubmed-meshheading:20848589-Cell Adhesion, pubmed-meshheading:20848589-Cell Cycle, pubmed-meshheading:20848589-Cell Movement, pubmed-meshheading:20848589-Cell Proliferation, pubmed-meshheading:20848589-Diterpenes, Abietane, pubmed-meshheading:20848589-Humans, pubmed-meshheading:20848589-Immunoenzyme Techniques, pubmed-meshheading:20848589-Male, pubmed-meshheading:20848589-Mice, pubmed-meshheading:20848589-Mice, SCID, pubmed-meshheading:20848589-Phenanthrenes, pubmed-meshheading:20848589-Prostatic Neoplasms, pubmed-meshheading:20848589-Protein-Serine-Threonine Kinases, pubmed-meshheading:20848589-RNA, Messenger, pubmed-meshheading:20848589-RNA, Small Interfering, pubmed-meshheading:20848589-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:20848589-Salvia miltiorrhiza, pubmed-meshheading:20848589-Tumor Cells, Cultured
pubmed:year
2011
pubmed:articleTitle
Bioactive tanshinones in Salvia miltiorrhiza inhibit the growth of prostate cancer cells in vitro and in mice.
pubmed:affiliation
Nutrition/Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural