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rdf:type |
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lifeskim:mentions |
umls-concept:C0009325,
umls-concept:C0010346,
umls-concept:C0017262,
umls-concept:C0021853,
umls-concept:C0123707,
umls-concept:C0185117,
umls-concept:C0205227,
umls-concept:C0851285,
umls-concept:C1135918,
umls-concept:C1261287,
umls-concept:C1979886,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-14
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pubmed:abstractText |
Stricture formation occurs in ?30% of patients with Crohn's disease (CD) and is a significant cause of morbidity. Strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, including collagen. Transforming growth factor-?1 (TGF-?1) has profibrotic effects in many tissues due to its ability to regulate collagen expression and extracellular matrix dynamics. We previously showed that both insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) and TGF-?1 are expressed by normal human intestinal smooth muscle cells, bind to, and activate TGF-?RII/I receptors in these cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1536-4844
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-201
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20848532-Adult,
pubmed-meshheading:20848532-Aged,
pubmed-meshheading:20848532-Blotting, Western,
pubmed-meshheading:20848532-Case-Control Studies,
pubmed-meshheading:20848532-Cells, Cultured,
pubmed-meshheading:20848532-Collagen Type I,
pubmed-meshheading:20848532-Constriction, Pathologic,
pubmed-meshheading:20848532-Crohn Disease,
pubmed-meshheading:20848532-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20848532-Female,
pubmed-meshheading:20848532-Humans,
pubmed-meshheading:20848532-Immunoenzyme Techniques,
pubmed-meshheading:20848532-Insulin-Like Growth Factor Binding Protein 3,
pubmed-meshheading:20848532-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:20848532-Intestinal Obstruction,
pubmed-meshheading:20848532-Intestines,
pubmed-meshheading:20848532-Male,
pubmed-meshheading:20848532-Middle Aged,
pubmed-meshheading:20848532-Myocytes, Smooth Muscle,
pubmed-meshheading:20848532-Prognosis,
pubmed-meshheading:20848532-RNA, Messenger,
pubmed-meshheading:20848532-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20848532-Transforming Growth Factor beta1,
pubmed-meshheading:20848532-Young Adult
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pubmed:year |
2011
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pubmed:articleTitle |
Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures.
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pubmed:affiliation |
Department of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0341, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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