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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-17
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pubmed:abstractText |
Sphingosine kinase 1 (SphK1) is an important regulator of apoptosis, survival, and proliferation in cancer cells. SphK1 expression in head and neck squamous cell cancer (HNSCC) cell lines and tumor tissue was assessed, and the efficacy of SphK1 knockdown in increasing tumor radiosensitivity was evaluated in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-0347
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Wiley Periodicals, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-88
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20848438-Animals,
pubmed-meshheading:20848438-Apoptosis,
pubmed-meshheading:20848438-Blotting, Western,
pubmed-meshheading:20848438-Carcinoma,
pubmed-meshheading:20848438-Carcinoma, Squamous Cell,
pubmed-meshheading:20848438-Disease Models, Animal,
pubmed-meshheading:20848438-Enzyme Inhibitors,
pubmed-meshheading:20848438-Head and Neck Neoplasms,
pubmed-meshheading:20848438-Humans,
pubmed-meshheading:20848438-Immunohistochemistry,
pubmed-meshheading:20848438-Male,
pubmed-meshheading:20848438-Mice,
pubmed-meshheading:20848438-Mice, Inbred BALB C,
pubmed-meshheading:20848438-Mice, Nude,
pubmed-meshheading:20848438-Neoplasms, Squamous Cell,
pubmed-meshheading:20848438-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:20848438-Polymerase Chain Reaction,
pubmed-meshheading:20848438-Radiation Tolerance,
pubmed-meshheading:20848438-Thiazoles,
pubmed-meshheading:20848438-Treatment Outcome
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pubmed:year |
2011
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|
pubmed:articleTitle |
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
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pubmed:affiliation |
Department of Otolaryngology - Head and Neck Surgery, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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