rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1991-5-16
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pubmed:abstractText |
The value of astaxanthin, a carotenoid pigment, in the treatment of oxidative injury is assessed. Astaxanthin protects the mitochondria of vitamin E-deficient rats from damage by Fe2(+)-catalyzed lipid peroxidation both in vivo and in vitro. The inhibitory effect of astaxanthin on mitochondrial lipid peroxidation is stronger than that of alpha-tocopherol. Thin layer chromatographic analysis shows that the change in phospholipid components of erythrocytes from vitamin E-deficient rats induced by Fe2+ and Fe3(+)-xanthine/xanthine oxidase system was significantly suppressed by astaxanthin. Carrageenan-induced inflammation of the paw is also significantly inhibited by administration of astaxanthin. These data indicate that astaxanthin functions as a potent antioxidant both in vivo and in vitro.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:issn |
0748-6642
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
27-38
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2084711-Animals,
pubmed-meshheading:2084711-Carotenoids,
pubmed-meshheading:2084711-Erythrocyte Membrane,
pubmed-meshheading:2084711-Iron,
pubmed-meshheading:2084711-Kinetics,
pubmed-meshheading:2084711-Lipid Peroxidation,
pubmed-meshheading:2084711-Male,
pubmed-meshheading:2084711-Mitochondria, Liver,
pubmed-meshheading:2084711-Oxidative Phosphorylation,
pubmed-meshheading:2084711-Rats,
pubmed-meshheading:2084711-Rats, Inbred Strains,
pubmed-meshheading:2084711-Reference Values,
pubmed-meshheading:2084711-Vitamin E,
pubmed-meshheading:2084711-Vitamin E Deficiency,
pubmed-meshheading:2084711-Xanthophylls,
pubmed-meshheading:2084711-beta Carotene
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pubmed:year |
1990
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pubmed:articleTitle |
Inhibition of oxidative injury of biological membranes by astaxanthin.
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pubmed:affiliation |
Department of Medical Biology, Kochi Medical School, Japan.
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pubmed:publicationType |
Journal Article
|