Linked Life Data

20846119

Source:http://linkedlifedata.com/resource/pubmed/id/20846119

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-9-17
pubmed:abstractText
Psoriasis is one of the commonest chronic inflammatory disorders. Its cause is unknown, but a wealth of studies indicate that the disease results from a complex and dynamic interplay between genetic and environmental factors that trigger an excessive inflammatory response in the skin. Dendritic cells and effector T-cells are central in the development of the psoriastic lesion, and cytokines produced by these cells stimulate keratinocytes to proliferate and increase the migration of inflammatory cells into the skin, promoting epidermal hyperplasia and inflammation. Understanding the immunology of the psoriatic plaque has led to new therapeutic options and novel candidates for immunomodulation, and has changed the ways psoriatic patients are managed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1470-8736
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-11
pubmed:dateRevised
2011-5-5
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Psoriasis: from pathogenesis to novel therapeutic approaches.
pubmed:affiliation
Gastroenterology Unit, Internal Medicine Department, University Tor Vergata of Rome, 00133 Rome, Italy. gi.monteleone@med.uniroma2.it
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't