Linked Life Data

20845993

Source:http://linkedlifedata.com/resource/pubmed/id/20845993

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-9-17
pubmed:abstractText
Wnt7a is a secreted glycoprotein that regulates normal cellular proliferation and differentiation as well as tumorigenesis and progression. The aim of this study was to investigate the expression and prognostic significance of Wnt7a in ovarian carcinoma. Wnt7a expression was immunohistochemically examined in normal ovaries (n=15), benign tumors (n=50) and ovarian carcinomas (n=78). The correlation of Wnt7a expression with clinicopathological parameters and survival was evaluated. Wnt7a expression was higher in ovarian carcinomas compared to normal ovaries and benign tumors (p<0.001 and p=0.001, respectively). Wnt7a positive expression was significantly correlated with serous subtype (p<0.001), elder age (p=0.017), advanced stage (p<0.001), high grade (p=0.001), a high degree of ascitic fluid volume (p=0.015) and high CA125 expression (p=0.025). Wnt7a was found to be a significant prognostic factor in univariate and multivariate analysis. High Wnt7a expression in ovarian cancer may be associated with poor prognosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-2685
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
545-51
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Prognostic role of Wnt7a expression in ovarian carcinoma patients.
pubmed:affiliation
Department of Obstetrics and Gynecology, Harbin Medical University, Harbin, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't