Linked Life Data

2084518

Source:http://linkedlifedata.com/resource/pubmed/id/2084518

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-5-10
pubmed:abstractText
Osteochondrosis is an impaired focal endochondral ossification which appears as a cartilage retention in the subchondral bone of growing pigs. The normal differentiation of chondrocytes does not occur and the matrix calcification is restricted. The present investigation has compared the content of selected macromolecules in the cartilage matrix of the normal articular and epiphyseal growth cartilage with the osteochondrotic cartilage, using a peroxidase-antiperoxidase (PAP) immunocytochemical method at light microscopical level. Some of the non-collagenous macromolecules (fibromodulin, large aggregating proteoglycans, fibronectin, 100-kDa subunit protein and 148-kDa protein) were conspicuously prominent within the osteochondrotic cartilage, compared to the matrix of the "normal" resting, proliferative and hypertrophic regions. This indicates that the chondrocytes in the osteochondrotic cartilage do not modify their surrounding matrix adequately, thus precluding normal calcification.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0934-8832
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
402-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Immunohistochemical localization of proteoglycans and non-collagenous matrix proteins in normal and osteochondrotic porcine articular-epiphyseal cartilage complex.
pubmed:affiliation
Department of Anatomy and Histology, Swedish University of Agricultural Sciences, Uppsala.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't