Source:http://linkedlifedata.com/resource/pubmed/id/20845098
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-9-16
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| pubmed:abstractText |
Routine regional lymphadenectomy for colorectal liver metastases and primary liver tumors is still a subject for debate. During 2001-2005, we performed a prospective study of cases in which regional lymphadenectomy around the hepato-duodenal ligament and common hepatic artery was applied (group R+ LN) or not (group R- LN). Pre-operative clinical features of patients were comparable among groups as well as the operative data. There were 108 (67%) males; the median age was 66 years; 124 cases had a single lesion (77%), and the median diameter was 4 cm. The type of lesion was: 77 (48%) colorectal liver metastases (M-CR), 75 (46%) hepatocellular carcinomas (HCC) and 10 (6%) cholangiocellular carcinomas. In the R+ LN group, the mean number of lymph nodes removed was 6.7 ± 4.8 (range 4-26), and seven cases (8.6%) presented lymph node metastasis. The median follow-up was 3.5 years. M-CR patients showed comparable hospital mortality (R+ LN 0% vs. R- LN 2.6%) and morbidity (R+ LN 17.9% vs. R- LN 21.1%), but R+ LN had higher 5-year disease-free survival (31 vs. 16%, p < 0.05). HCC cases in the R+ LN group presented higher hospital mortality (13.5 vs. 0%, p < 0.05) without any improvement in disease-free survival (it was at 5-year disease-free survival 34 vs. 33%, respectively, p = n.s.). Routine regional lymphadenectomy should be performed for colorectal liver metastases, and avoided in patients with hepatocellular carcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
2038-131X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
62
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
27-34
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| pubmed:meshHeading |
pubmed-meshheading:20845098-Aged,
pubmed-meshheading:20845098-Disease-Free Survival,
pubmed-meshheading:20845098-Female,
pubmed-meshheading:20845098-Humans,
pubmed-meshheading:20845098-Liver Neoplasms,
pubmed-meshheading:20845098-Lymph Node Excision,
pubmed-meshheading:20845098-Male,
pubmed-meshheading:20845098-Neoplasm Metastasis,
pubmed-meshheading:20845098-Prognosis,
pubmed-meshheading:20845098-Prospective Studies,
pubmed-meshheading:20845098-Safety
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| pubmed:year |
2010
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| pubmed:articleTitle |
Safety and prognostic role of regional lymphadenectomy for primary and metastatic liver tumors.
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| pubmed:affiliation |
Department of Surgery and Organ Transplantation, Sant'Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. mrava1@hotmail.com
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| pubmed:publicationType |
Journal Article
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