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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-10-18
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pubmed:abstractText |
Glycodelin-A interacts with spermatozoa before fertilization, but its role in modulating sperm functions is not known. Zona pellucida-induced acrosome reaction is crucial to fertilization and its dysfunction is a cause of male infertility. We hypothesized that glycodelin-A, a glycoprotein found in the female reproductive tract, potentiates human spermatozoa for zona pellucida-induced acrosome reaction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Signal-Regulated MAP...,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/PAEP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnancy Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1460-2350
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pubmed:author |
pubmed-author:ChiuPhilip C NPC,
pubmed-author:ChungMan-KinMK,
pubmed-author:GuptaSatish KSK,
pubmed-author:KoistinenHannuH,
pubmed-author:KoistinenRiittaR,
pubmed-author:LamKevin K WKK,
pubmed-author:LeeCheuk-LunCL,
pubmed-author:LeeKai-FaiKF,
pubmed-author:SeppäläMarkkuM,
pubmed-author:WongBen S TBS,
pubmed-author:YeungWilliam S BWS
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2721-33
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pubmed:meshHeading |
pubmed-meshheading:20843776-Acrosome Reaction,
pubmed-meshheading:20843776-Adenylate Cyclase,
pubmed-meshheading:20843776-Calcium,
pubmed-meshheading:20843776-Cyclic AMP,
pubmed-meshheading:20843776-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:20843776-Down-Regulation,
pubmed-meshheading:20843776-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:20843776-Female,
pubmed-meshheading:20843776-Glycoproteins,
pubmed-meshheading:20843776-Glycosylation,
pubmed-meshheading:20843776-Humans,
pubmed-meshheading:20843776-Inositol 1,4,5-Trisphosphate Receptors,
pubmed-meshheading:20843776-Male,
pubmed-meshheading:20843776-Pregnancy Proteins,
pubmed-meshheading:20843776-Spermatozoa,
pubmed-meshheading:20843776-Up-Regulation,
pubmed-meshheading:20843776-Zona Pellucida
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pubmed:year |
2010
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pubmed:articleTitle |
Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx.
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pubmed:affiliation |
Department of Obstetrics and Gynaecology, University of Hong Kong, Pokfulam Road, Hong Kong, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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