Linked Life Data

20843688

Source:http://linkedlifedata.com/resource/pubmed/id/20843688

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
2010-10-11
pubmed:abstractText
In this Letter, an efficient strategy for the fast construction of 108 compounds library was developed using click chemistry. The fingerprint of inhibitory activity toward MAO-A/B against this library was obtained, and four hit compounds were identified as selective inhibitors toward MAO-A. Docking study was carried out to demonstrate the binding mode between a9 and MAO-A/B, and the result reveals that a9 localized in the 'aromatic cage' and oriented to establish ?-? stacking interactions with Tyr407, Tyr444 and FAD in MAO-A rather than in MAO-B.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1464-3405
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6222-5
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
'Click' assembly of selective inhibitors for MAO-A.
pubmed:affiliation
Institute of Bioengineering, Zhejiang University of Technology (chaohui campus), Hangzhou 310014, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't