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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-10-7
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pubmed:abstractText |
Several studies demonstrated that epidermal growth factor receptor (EGFR) gene copy number (GCN) correlates to the response to tyrosine kinase inhibitors in non small cell lung cancer (NSCLC) and to anti-EGFR monoclonal antibodies (MoAbs) in metastatic colorectal cancer (CRC). In the presence of lung nodules, cytology is often the only possible diagnostic approach. Chromogenic in situ hybridization (CISH) is an alternative technique to fluorescence in situ hybridization (FISH), but its feasibility in detecting EGFR GCN in cell blocks from fine-needle aspiration cytology (FNAC) of lung nodules has not yet been established.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1756-9966
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125
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pubmed:meshHeading |
pubmed-meshheading:20843314-Adult,
pubmed-meshheading:20843314-Aged,
pubmed-meshheading:20843314-Aged, 80 and over,
pubmed-meshheading:20843314-Aneuploidy,
pubmed-meshheading:20843314-Biopsy, Fine-Needle,
pubmed-meshheading:20843314-Biotin,
pubmed-meshheading:20843314-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:20843314-Chromogenic Compounds,
pubmed-meshheading:20843314-Chromosomes, Human, Pair 7,
pubmed-meshheading:20843314-Colorectal Neoplasms,
pubmed-meshheading:20843314-Digoxigenin,
pubmed-meshheading:20843314-Feasibility Studies,
pubmed-meshheading:20843314-Female,
pubmed-meshheading:20843314-Gene Dosage,
pubmed-meshheading:20843314-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20843314-Humans,
pubmed-meshheading:20843314-Immunohistochemistry,
pubmed-meshheading:20843314-In Situ Hybridization,
pubmed-meshheading:20843314-In Situ Hybridization, Fluorescence,
pubmed-meshheading:20843314-Italy,
pubmed-meshheading:20843314-Lung Neoplasms,
pubmed-meshheading:20843314-Male,
pubmed-meshheading:20843314-Middle Aged,
pubmed-meshheading:20843314-Predictive Value of Tests,
pubmed-meshheading:20843314-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20843314-Reproducibility of Results,
pubmed-meshheading:20843314-Retrospective Studies
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pubmed:year |
2010
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pubmed:articleTitle |
Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer.
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pubmed:affiliation |
Pathology Department, Giovanni Paolo II National Cancer Institute, via Hahnemann 10, Bari, Italy. g.simone@oncologico.bari.it
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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