Source:http://linkedlifedata.com/resource/pubmed/id/20842727
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2010-10-14
|
| pubmed:abstractText |
Predicting evolution of small node-negative breast carcinoma is a real challenge in clinical practice. The aim of this study was to search whether qualitative or quantitative DNA changes may help to predict metastasis of small node-negative breast carcinoma. Small invasive ductal carcinomas without axillary lymph node involvement (T1T2N0) from 168 patients with either good (111 patients with no event at 5 years after diagnosis) or poor (57 patients with early metastasis) outcome were analyzed with comparative genomic hybridization (CGH) array. A CGH classifier, identifying low- and high-risk groups of metastatic recurrence, was established in a training set of 78 patients, then validated, and compared with clinicopathological parameters in a distinct set of 90 patients. The genomic status of regions located on 2p22.2, 3p23, and 8q21-24 and the number of segmental alterations were defined in the training set to classify tumors into low- or high-risk groups. In the validation set, in addition to estrogen receptors and grade, this CGH classifier provided significant prognostic information in multivariate analysis (odds ratio, 3.34; 95% confidence interval 1.01-11.02; P = 4.78 × 10(-2), Wald test). This study shows that tumor DNA contains important prognostic information that may help to predict metastasis in T1T2N0 tumors of the breast.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1098-2264
|
| pubmed:author |
pubmed-author:AsselainBernardB,
pubmed-author:De RyckeYannY,
pubmed-author:DelattreOlivierO,
pubmed-author:FourquetAlainA,
pubmed-author:GravierEléonoreE,
pubmed-author:GruelNadègeN,
pubmed-author:LucchesiCarloC,
pubmed-author:PiergaJean-YvesJY,
pubmed-author:PierronGaëlleG,
pubmed-author:RadvanyiFrançoisF,
pubmed-author:RaynalVirginieV,
pubmed-author:ReyalFabienF,
pubmed-author:Roman-RomanSergioS,
pubmed-author:Sastre-GarauXavierX,
pubmed-author:SavignoniAlexiaA,
pubmed-author:Vincent-SalomonAnneA
|
| pubmed:copyrightInfo |
© 2010 Wiley-Liss, Inc.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1125-34
|
| pubmed:meshHeading |
pubmed-meshheading:20842727-Breast Neoplasms,
pubmed-meshheading:20842727-Carcinoma, Ductal, Breast,
pubmed-meshheading:20842727-Case-Control Studies,
pubmed-meshheading:20842727-Chromosomes, Human, Pair 2,
pubmed-meshheading:20842727-Chromosomes, Human, Pair 3,
pubmed-meshheading:20842727-Chromosomes, Human, Pair 8,
pubmed-meshheading:20842727-Comparative Genomic Hybridization,
pubmed-meshheading:20842727-Cytogenetic Analysis,
pubmed-meshheading:20842727-DNA, Neoplasm,
pubmed-meshheading:20842727-Female,
pubmed-meshheading:20842727-Gene Expression Profiling,
pubmed-meshheading:20842727-Humans,
pubmed-meshheading:20842727-Lymph Nodes,
pubmed-meshheading:20842727-Lymphatic Metastasis,
pubmed-meshheading:20842727-Neoplasm Metastasis,
pubmed-meshheading:20842727-Neoplasm Recurrence, Local,
pubmed-meshheading:20842727-Outcome Assessment (Health Care),
pubmed-meshheading:20842727-Prognosis,
pubmed-meshheading:20842727-Receptors, Estrogen,
pubmed-meshheading:20842727-Risk Assessment
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
A prognostic DNA signature for T1T2 node-negative breast cancer patients.
|
| pubmed:affiliation |
Department of Translational Research, Institut Curie, 26 rue d’Ulm, Paris, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|