Linked Life Data

20842205

Source:http://linkedlifedata.com/resource/pubmed/id/20842205

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-9-15
pubmed:abstractText
Whether or not HIV gp120-elicited signal transduction through the coreceptors CCR5 and CXCR4 is required for productive viral replication has long been a subject of controversy. The complexity and diversity of G protein signal transduction initiated by chemokine receptor activation has hindered efforts to understand the contributions of these pathways to the HIV life cycle. Several recent studies have demonstrated an important role for G proteins in mediating signaling events through both CCR5 and CXCR4 that are necessary for productive HIV infection. In addition to gp120-mediated G protein activation, there is still much to learn about the impact of G protein signaling during HIV infection, including the role of T-cell receptor/CXCR4 cross-talk, regulation of G protein expression during infection and the contribution of G protein subunit genetic polymorphisms to disease progression. This review will describe the effects of G protein signaling in immune cells, summarize the current understanding of CCR5 and CXCR4-initiated signal transduction in HIV replication, and discuss important gaps that still remain in our understanding of G protein signaling and its contribution to HIV pathogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1698-6997
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
164-76
pubmed:meshHeading
pubmed:articleTitle
Clarifying the role of G protein signaling in HIV infection: new approaches to an old question.
pubmed:affiliation
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't