Linked Life Data

20840164

Source:http://linkedlifedata.com/resource/pubmed/id/20840164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-9-15
pubmed:abstractText
Epigenetics holds promise to explain some puzzles concerning the risk and course of psychiatric disorders. Epigenetic information is essential as a set of operating instructions for the genome, which is heritable with DNA. The epigenetic regulation of gene expression can plausibly be influenced by the environment of one's ancestors, prenatal exposures, and by early life events. Some epigenetic mechanisms may alter neurophysiology throughout life by programming gene expression, perhaps in anticipation of certain life experiences. These epigenetic signals are only meta-stable and may be perturbed by stochastic events, errors, or by environmental toxins. This introduction considers the possibility that epigenetic change that may occur as paternal age advances or during fetal adversity may be causally related to the susceptibility for schizophrenia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1749-6632
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
1204 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E8-13
pubmed:dateRevised
2011-2-18
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Critical periods and the developmental origins of disease: an epigenetic perspective of schizophrenia.
pubmed:affiliation
New York University School of Medicine, Social and Psychiatric Initiatives (InSPIRES), New York, New York 10016, USA.
pubmed:publicationType
Journal Article