Linked Life Data

20840075

Source:http://linkedlifedata.com/resource/pubmed/id/20840075

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-9-15
pubmed:abstractText
Aneuploidy is one of the major hallmarks of cancer cells and several paths towards aneuploidy have been described. However, the relevance for tumor initiation or progression and how tumors deal with the initial aneuploidy related stress response is still unclear and recent results suggest that aneuploidy can even have tumor suppressive effects under certain conditions. The molecular mechanisms leading to and sustaining growth of aneuploid cells are just at the beginning to be understood and might provide new targets for cancer drug development. We will discuss some of the ideas to specifically kill aneuploid cells by targeting key regulators of mitosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1873-5592
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1325-35
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Destabilizing aneuploidy by targeting cell cycle and mitotic checkpoint proteins in cancer cells.
pubmed:affiliation
Nerviano Medical Sciences S.r.l., Viale Pasteur 10, I-20014 Nerviano (Mi), Italy.
pubmed:publicationType
Journal Article, Review