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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-10-11
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pubmed:abstractText |
Star polymers with thermoresponsive arms, consisting of 2-(2-methoxyethoxy)ethyl methacrylate (MEO?MA) and oligo(ethylene glycol) methacrylate with ~4 ethylene oxide units (OEOMA???, M(n) = 300), were synthesized via atom transfer radical polymerization (ATRP). 25% of the arms contained benzophenone chain-end functionality at the star periphery. A mixture of linear poly(MEO?MA-co-OEOMA???)-Br macroinitiators without and with benzophenone end-group macroinitiators were (MI and Bzp-MI, respectively) cross-linked with ethylene glycol dimethacrylate to form star polymers. Formation of star polymers was monitored by GPC, and the presence of benzophenone functionality in the stars was confirmed by ¹H NMR. The UV-vis spectroscopy revealed that the star polymers exhibit the low critical solution temperature (LCST) at 27 °C, slightly lower than LCST of either MI or Bzp-MI. Commercially available tissue culture grade polystyrene surface was modified by depositing a thin film of functionalized stars and UV cross-linking (? = 365 nm). The star polymers covalently attached onto surfaces allowed a control of cell shrinkage and attachment in response to temperature changes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1526-4602
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2647-52
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pubmed:meshHeading |
pubmed-meshheading:20839794-Animals,
pubmed-meshheading:20839794-Benzophenones,
pubmed-meshheading:20839794-Cell Adhesion,
pubmed-meshheading:20839794-Cell Survival,
pubmed-meshheading:20839794-Cross-Linking Reagents,
pubmed-meshheading:20839794-Ethylene Oxide,
pubmed-meshheading:20839794-Magnetic Resonance Spectroscopy,
pubmed-meshheading:20839794-Methacrylates,
pubmed-meshheading:20839794-Mice,
pubmed-meshheading:20839794-Microscopy, Phase-Contrast,
pubmed-meshheading:20839794-Molecular Structure,
pubmed-meshheading:20839794-NIH 3T3 Cells,
pubmed-meshheading:20839794-Photochemical Processes,
pubmed-meshheading:20839794-Polymerization,
pubmed-meshheading:20839794-Polymers,
pubmed-meshheading:20839794-Polystyrenes,
pubmed-meshheading:20839794-Surface Properties,
pubmed-meshheading:20839794-Temperature,
pubmed-meshheading:20839794-Ultraviolet Rays
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pubmed:year |
2010
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pubmed:articleTitle |
Photo-cross-linkable thermoresponsive star polymers designed for control of cell-surface interactions.
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pubmed:affiliation |
Department of Chemistry, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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