Linked Life Data

20837333

Source:http://linkedlifedata.com/resource/pubmed/id/20837333

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-9-14
pubmed:abstractText
Allogeneic haematopoietic stem cell transplantation (HSCT) remains an important treatment option for patients with chronic myeloid leukaemia (CML) failing tyrosine-kinase inhibitors or progressing to an advanced phase. In this setting, umbilical cord blood (UCB) could be used as an alternative stem cell source for patients in whom allogeneic HSCT is indicated and lack a human leucocyte antigen (HLA)-matched adult donor. However, very little information exists on the outcome after UCB transplantation (UCBT) of these patients. Early registry-based studies of patients undergoing UCBT suggested a particularly poor outcome for patients with CML. However, more recent reports with special focus on patients with CML have confirmed feasibility and efficacy of the procedure and identified variables influencing short- and long-term outcomes. Currently, UCBT should be considered as a potential curative alternative for CML patients requiring allogeneic HSCT but lacking an appropriate adult donor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1532-1924
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-22
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Umbilical cord blood transplantation from unrelated donors in adult patients with chronic myeloid leukaemia.
pubmed:affiliation
Department of Hematology, Hospital Universitario La Fe, Valencia, Spain.
pubmed:publicationType
Journal Article, Review