|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-12-3
|
|
pubmed:abstractText |
The tumor suppressor PTEN inhibits AKT2 signaling; both are aberrantly expressed in liver tumors. We investigated how PTEN and AKT2 regulate liver carcinogenesis. Loss of PTEN leads to spontaneous development of liver tumors from progenitor cells. We investigated how the loss of PTEN activates liver progenitor cells and induces tumorigenesis.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1528-0012
|
|
pubmed:author |
pubmed-author:BayanJennifer-AnnJA,
pubmed-author:BirnbaumMorris JMJ,
pubmed-author:DangHienH,
pubmed-author:DingWeiW,
pubmed-author:FrenchBarbara ABA,
pubmed-author:FrenchSamuelS,
pubmed-author:GaliciaVivian AVA,
pubmed-author:HeLinaL,
pubmed-author:KanelGaryG,
pubmed-author:RountreeC BartCB,
pubmed-author:StilesBangyan LBL,
pubmed-author:VendryesChristopherC,
pubmed-author:WangKasper SKS,
pubmed-author:ZengNiN
|
|
pubmed:copyrightInfo |
Copyright © 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
139
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2170-82
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:20837017-Animals,
pubmed-meshheading:20837017-Cell Line,
pubmed-meshheading:20837017-Cell Survival,
pubmed-meshheading:20837017-Cell Transformation, Neoplastic,
pubmed-meshheading:20837017-Drug-Induced Liver Injury,
pubmed-meshheading:20837017-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20837017-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:20837017-Liver Neoplasms,
pubmed-meshheading:20837017-Mice,
pubmed-meshheading:20837017-Mice, Inbred C57BL,
pubmed-meshheading:20837017-Mice, Mutant Strains,
pubmed-meshheading:20837017-PTEN Phosphohydrolase,
pubmed-meshheading:20837017-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20837017-Pyridines,
pubmed-meshheading:20837017-Signal Transduction,
pubmed-meshheading:20837017-Stem Cells
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.
|
|
pubmed:affiliation |
Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
