Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase.
Infectious diseases and immunology Division, Indian Institute of Chemical Biology, A Unit of Council of Scientific and Industrial Research, Govt, of India; 4, Raja S, C, Mullick Road, Kolkata 700032, India. cmandal@iicb.res.in.