Linked Life Data

20836742

Source:http://linkedlifedata.com/resource/pubmed/id/20836742

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-10-7
pubmed:abstractText
Thymosin beta-10 (T?10) is a member of beta-thymosins (T?s), a family of low molecular mass peptides, which play essential roles in many cellular functions, including apoptosis, cell proliferation, cell migration, and endocytosis. The report that the T?10 gene is expressed at high levels in embryonic human brain as well in human kidney induced us to study T?10 reactivity in the preterm kidney in order to verify, at tissue level, the expression of this peptide during renal embryogenesis. To this end, we analyzed, using immunocytochemistry, the expression of T?10 in samples of human kidney obtained, at autopsy, from 8 fetuses, 12 preterm infants, ranging from 25 to 36 weeks of gestation and 3 at term newborns. T?10 immunoreactivity was detected in 20 out of 22 kidneys examined, and was mainly localized in proximal and distal tubular structures, in the cytoplasm and occasionally in the nuclei of ductal cells. In 11 cases, we also detected a focal and mild reactivity for the peptide in glomeruli. In 13 kidneys, we also observed immunostaining for T?10 inside the "comma-shaped bodies" and the "S-shaped bodies" during active glomerulogenesis. Our data show, for the first time, the expression of T?10 in the human kidney during the initial phases of its physiological development, mainly restricted in the proximal and the distal tubuli. Further studies are needed in order to better characterize the role of T?10 in kidney embryogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1476-4954
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
23 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Thymosin beta-10 expression in developing human kidney.
pubmed:affiliation
Department of Pathology, University of Cagliari, Cagliari, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't