Source:http://linkedlifedata.com/resource/pubmed/id/20836552
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
19
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| pubmed:dateCreated |
2010-10-7
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| pubmed:abstractText |
Previous studies have suggested that garlic oil could protect the cardiovascular system. However, the mechanism by which garlic oil protects diabetes-induced cardiomyopathy is unclear. In this study, streptozotocin (STZ)-induced diabetic rats received garlic oil (0, 10, 50, or 100 mg/kg of body weight) by gastric gavage every 2 days for 16 days. Normal rats without diabetes were used as control. Cardiac contractile dysfunction examined by echocardiography and apoptosis evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay were observed in diabetic rat hearts. Additionally, a shift in cardiac myosin heavy chain (MHC) gene expression from ?- to ?-MHC isoform, decreased levels of superoxide dismutase-1 (SOD-1) and cardiac ?-actin, and elevated cardiac thiobarbituric acid reactive substances (TBARS) and caspase- and p38-NF?B-leading apoptosis signaling activities were demonstrated in diabetic hearts. However, these diabetes-related cardiac dysfunctions were almost dose-dependently ameliorated by garlic oil administration. In conclusion, garlic oil possesses significant potential for protecting hearts from diabetes-induced cardiomyopathy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Heavy Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfides,
http://linkedlifedata.com/resource/pubmed/chemical/allyl sulfide
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| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1520-5118
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
13
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| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
10347-55
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| pubmed:meshHeading |
pubmed-meshheading:20836552-Allyl Compounds,
pubmed-meshheading:20836552-Animals,
pubmed-meshheading:20836552-Antioxidants,
pubmed-meshheading:20836552-Apoptosis,
pubmed-meshheading:20836552-Caspases,
pubmed-meshheading:20836552-Diabetes Mellitus, Experimental,
pubmed-meshheading:20836552-Diabetic Cardiomyopathies,
pubmed-meshheading:20836552-Dose-Response Relationship, Drug,
pubmed-meshheading:20836552-Gene Expression,
pubmed-meshheading:20836552-In Situ Nick-End Labeling,
pubmed-meshheading:20836552-Male,
pubmed-meshheading:20836552-Myocardial Contraction,
pubmed-meshheading:20836552-Myocardium,
pubmed-meshheading:20836552-Myosin Heavy Chains,
pubmed-meshheading:20836552-Phytotherapy,
pubmed-meshheading:20836552-Rats,
pubmed-meshheading:20836552-Rats, Wistar,
pubmed-meshheading:20836552-Sulfides
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| pubmed:year |
2010
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| pubmed:articleTitle |
Cardiac contractile dysfunction and apoptosis in streptozotocin-induced diabetic rats are ameliorated by garlic oil supplementation.
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| pubmed:affiliation |
Department of Physical Therapy and Graduate Institute of Rehabilitation Science, China Medical University, 91 Hsueh-ShihRoad, Taichung 404, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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