|
rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0003451,
umls-concept:C0011306,
umls-concept:C0019168,
umls-concept:C0019169,
umls-concept:C0021311,
umls-concept:C0035647,
umls-concept:C0205191,
umls-concept:C0439662,
umls-concept:C0444669,
umls-concept:C1522326,
umls-concept:C1709060,
umls-concept:C1947910
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pubmed:issue |
6
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|
pubmed:dateCreated |
2010-9-13
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|
pubmed:abstractText |
Commercially available prophylactic vaccines containing hepatitis B surface antigen (HBsAg), which are used to prevent HBV infections, are not as effective as a therapeutic immune modulator for treating patients with chronic hepatitis B (CHB). In this study, the immunogenicity of dendritic cells (DC) loaded with both HBsAg and hepatitis B core antigen (HBcAg) was tested in HBV transgenic mice (TM; 1.2HB-BS10) in vivo and in patients with CHB in vitro.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:issn |
2040-2058
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|
pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
15
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
887-95
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pubmed:meshHeading |
pubmed-meshheading:20834101-Adult,
pubmed-meshheading:20834101-Animals,
pubmed-meshheading:20834101-Antiviral Agents,
pubmed-meshheading:20834101-Cells, Cultured,
pubmed-meshheading:20834101-Dendritic Cells,
pubmed-meshheading:20834101-Hepatitis B, Chronic,
pubmed-meshheading:20834101-Hepatitis B Antibodies,
pubmed-meshheading:20834101-Hepatitis B Core Antigens,
pubmed-meshheading:20834101-Hepatitis B Surface Antigens,
pubmed-meshheading:20834101-Hepatitis B Vaccines,
pubmed-meshheading:20834101-Humans,
pubmed-meshheading:20834101-Male,
pubmed-meshheading:20834101-Mice,
pubmed-meshheading:20834101-Mice, Inbred C57BL,
pubmed-meshheading:20834101-Mice, Transgenic,
pubmed-meshheading:20834101-Middle Aged,
pubmed-meshheading:20834101-Spleen,
pubmed-meshheading:20834101-T-Lymphocytes,
pubmed-meshheading:20834101-Vaccination,
pubmed-meshheading:20834101-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Immune modulator and antiviral potential of dendritic cells pulsed with both hepatitis B surface antigen and core antigen for treating chronic HBV infection.
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pubmed:affiliation |
Department of Medical Sciences, Toshiba General Hospital, Tokyo, Japan. sheikh.akbar@po.toshiba.co.jp
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pubmed:publicationType |
Journal Article
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