Linked Life Data

2083359

Source:http://linkedlifedata.com/resource/pubmed/id/2083359

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1991-5-10
pubmed:abstractText
The attempt was performed to isolate desialylated low density lipoproteins (LDL) from the blood of healthy subjects and patients with coronary heart disease by affinity chromatography with immobilized agglutinin of Ricinus communis, a lectin that interacts specifically with galactose residues. A part of LDL was bound to sorbent and could be replaced by galactose but not other saccharide constituents of the LDL molecule. Bound LDL subfraction had a 2-3-fold lower content of desialylated LDL in CAD patients was about 3-fold higher than in healthy subjects. Desialylated LDL induced a 2- to 4-fold increase of total cholesterol content in cultured human aortic intimal cells, whereas unbound LDL had no effect on intracellular cholesterol level. It is assumed that the subfraction of desialylated LDL may be responsible for the atherogenic properties of LDL in CAD patients.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0365-9615
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
606-9
pubmed:dateRevised
2008-10-8
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Isolation of desialylated low density lipoproteins from the blood of patients with ischemic heart disease by affinity chromatography].
pubmed:publicationType
Journal Article, Comparative Study, English Abstract