Linked Life Data

20833211

Source:http://linkedlifedata.com/resource/pubmed/id/20833211

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-11-12
pubmed:abstractText
Anticonvulsant properties of ?-asarone were studied in mice at three doses with different toxicity. The 100mg/kg dose decreased both treadmill performance and locomotor activity, caused hypothermia, and potentiated pentobarbital-induced sleep. The last two effects and no toxicity were observed at 60 and 22mg/kg, respectively. In chemical (pentylenetetrazole, picrotoxin, N-methyl-D-aspartate, pilocarpine) and electrical (maximal electroshock) seizure tests, neither seizures nor death were prevented by 60 mg/kg ?-asarone which, however, exhibited protective-like effects (delay in the onset of clonic and/or tonic seizures and/or in the death of mice). Magnesium deficiency-dependent audiogenic seizures responded to non-toxic doses of ?-asarone (60 mg/kg and less): 22 mg/kg protecting 50% of tested animals. Because these seizures respond to both anti-seizure and antioxidant compounds, antioxidant properties of ?-asarone were studied, indicating 5 Units of superoxide dismutase-like activity per mg ?-asarone. Treatment of mice by ?-asarone (daily dose of 100mg/kg during 7 days) induced brain antioxidant enzymes (superoxide dismutase, glutathione peroxidase and reductase) in striatum and hippocampus and to a lesser extent in cortex. In view of recent findings about deleterious roles of chronic inflammatory/oxidant stresses in human epilepsy outcome, antioxidant and inductive properties of ?-asarone are proposed to be coherent bases for traditional clinical efficacy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1872-8111
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-44
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Activities of ?-asarone in various animal seizure models and in biochemical assays might be essentially accounted for by antioxidant properties.
pubmed:affiliation
Toxicology Laboratory, Faculty of Pharmacy, Illkirch, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't