|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
20
|
|
pubmed:dateCreated |
2010-9-20
|
|
pubmed:abstractText |
A series of azulene-based derivatives were synthesized as potent inhibitors for receptor tyrosine kinases such as FMS-like tyrosine kinase 3 (FLT-3). Systematic side chain modification of prototype 1a was carried out through SAR studies. Analogue 22 was identified from this series and found to be one of the most potent FLT-3 inhibitors, with good pharmaceutical properties, superior efficacy, and tolerability in a tumor xenograft model.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
pubmed-author:ChangChia-NiCN,
pubmed-author:ChangMay-HuaMH,
pubmed-author:ChangYow-LoneYL,
pubmed-author:ChangYu-LiYL,
pubmed-author:ChenChih-HungCH,
pubmed-author:ChenTing-ShouTS,
pubmed-author:ChenYen-ChunYC,
pubmed-author:ChiouShu-JiauSJ,
pubmed-author:ChouNien-TzuNT,
pubmed-author:ChouShuen-HsiangSH,
pubmed-author:ChuangMeng-YunMY,
pubmed-author:HseuTzong-HsiungTH,
pubmed-author:HsuHui-ChunHC,
pubmed-author:HsuYi-LingYL,
pubmed-author:HuTsan-LinTL,
pubmed-author:HwangChrong-ShiongCS,
pubmed-author:JUDJJ,
pubmed-author:KoChing-HuaiCH,
pubmed-author:LaiChin-PenCP,
pubmed-author:LinChih-LungCL,
pubmed-author:LinHui-ChiHC,
pubmed-author:LinMai-WeiMW,
pubmed-author:LiuChih-PengCP,
pubmed-author:LiuChung-ChengCC,
pubmed-author:ShihYing-ChuYC,
pubmed-author:SunChung-YuanCY,
pubmed-author:TsaiYuan-JangYJ,
pubmed-author:TsengHsiang-WenHW,
pubmed-author:TuChia-MuCM,
pubmed-author:WangLing-meiLM,
pubmed-author:WenYen-FangYF,
pubmed-author:YangWan-HsuWH,
pubmed-author:YaoChung-NiangCN
|
|
pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6129-32
|
|
pubmed:meshHeading |
pubmed-meshheading:20833039-Animals,
pubmed-meshheading:20833039-Antineoplastic Agents,
pubmed-meshheading:20833039-Azulenes,
pubmed-meshheading:20833039-Cell Line, Tumor,
pubmed-meshheading:20833039-Cell Proliferation,
pubmed-meshheading:20833039-Humans,
pubmed-meshheading:20833039-Leukemia, Myeloid, Acute,
pubmed-meshheading:20833039-Mice,
pubmed-meshheading:20833039-Mice, Inbred BALB C,
pubmed-meshheading:20833039-Mice, Nude,
pubmed-meshheading:20833039-Rats,
pubmed-meshheading:20833039-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:20833039-fms-Like Tyrosine Kinase 3
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Novel azulene-based derivatives as potent multi-receptor tyrosine kinase inhibitors.
|
|
pubmed:affiliation |
Biomedical Engineering Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan. ChihHungChen@itri.org.tw
|
|
pubmed:publicationType |
Journal Article
|
