Linked Life Data

20831202

Source:http://linkedlifedata.com/resource/pubmed/id/20831202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
40
pubmed:dateCreated
2010-10-7
pubmed:abstractText
An efficient total synthesis of the antiproliferative macrolide and cell migration inhibitor lactimidomycin (3) is reported, which relies on the performance of ring closing alkyne metathesis (RCAM). The strained 12-membered 1,3-enyne 21 as the key intermediate was forged with the aid of [(Ph(3)SiO)(3)Mo?CPh]·OEt(2) (27) as the most effective member of a new generation of powerful alkyne metathesis catalysts. 21 was elaborated to the target by a ruthenium catalyzed trans-hydrosilylation/proto-desilylation sequence and a highly diastereoselective Mukaiyama aldol reaction controlled by oxazaborolidinone 29 as strategic operations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1520-5126
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14064-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Concise total synthesis of the potent translation and cell migration inhibitor lactimidomycin.
pubmed:affiliation
Max-Planck-Institut fu?r Kohlenforschung, D-45470 Mu?lheim/Ruhr, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't