Linked Life Data

20830329

Source:http://linkedlifedata.com/resource/pubmed/id/20830329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-9-21
pubmed:abstractText
An ideal fluorescent probe should show the strongest affinity with the relevant target (binding-selectivity) by means of a selective fluorescence change (signal-selectivity). [15]aneNO(2)S(2) (1,4-dioxa-7,13-dithia-10-azacyclopentadecane) based probes usually show high binding selectivity for Ag(+) but signal selectivity for Hg(2+), because Ag(+) can quench or silence the fluorescence. To amplify the Ag(+) binding to the greatest extent, a carbonyl group was positioned between 1,8-naphthalimide and [15]aneNO(2)S(2) which played a key role of displaying selective fluorescence enhancements with Ag(+) through increasing the oxidation potential of the fluorophore, blocking Ag(+) from sterically interacting with the naphthalimide fluorophore, and by acting as a sacrificial donor. Probe 2 can detect Ag(+) with a selective fluorescence enhancement (?14 fold) and high affinity (K(a) = 1.64 × 10(5) M(-1)).
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1364-5528
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2554-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Discovery of a highly selective turn-on fluorescent probe for Ag+.
pubmed:affiliation
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't