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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-29
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pubmed:abstractText |
?Np63? is a critical pro-survival protein overexpressed in 80% of head and neck squamous cell carcinomas (HNSCCs) where it inhibits TAp73? transcription of p53-family target genes, which is thought to increase HNSCC resistance to chemotherapy-induced cell death. However, the mechanisms governing ?Np63? function are largely unknown. In this study, we identify special AT-rich-binding protein 2 (SATB2) as a new ?Np63?-binding protein that is preferentially expressed in advanced-stage primary HNSCC and show that SATB2 promotes chemoresistance by enhancing ?Np63?-mediated transrepression by augmenting ?Np63? engagement to p53-family responsive elements. Furthermore, SATB2 expression positively correlates with HNSCC chemoresistance, and RNA interference-mediated knockdown of endogenous SATB2 re-sensitizes HNSCC cells to chemotherapy- and ?-irradiation-induced apoptosis, irrespective of p53 status. These findings unveil SATB2 as a pivotal modulator of ?Np63? that governs HNSCC cell survival.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1469-3178
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pubmed:author |
pubmed-author:ChengLynn SLS,
pubmed-author:ChungJackyJ,
pubmed-author:GrantR IanRI,
pubmed-author:IrwinMeredith SMS,
pubmed-author:Kamel-ReidSuzanneS,
pubmed-author:KaplanDavid RDR,
pubmed-author:KetelaTroyT,
pubmed-author:LauJoanneJ,
pubmed-author:MoffatJasonJ,
pubmed-author:OhhMichaelM,
pubmed-author:Perez-OrdonezBayardoB,
pubmed-author:ReisPatricia PPP,
pubmed-author:RobinsonFionaF,
pubmed-author:RocheOlgaO
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
777-83
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:20829881-Apoptosis,
pubmed-meshheading:20829881-Carcinoma, Squamous Cell,
pubmed-meshheading:20829881-Cell Line, Tumor,
pubmed-meshheading:20829881-Cell Survival,
pubmed-meshheading:20829881-DNA-Binding Proteins,
pubmed-meshheading:20829881-Drug Resistance, Neoplasm,
pubmed-meshheading:20829881-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20829881-Genes, p53,
pubmed-meshheading:20829881-Head and Neck Neoplasms,
pubmed-meshheading:20829881-Humans,
pubmed-meshheading:20829881-Matrix Attachment Region Binding Proteins,
pubmed-meshheading:20829881-Trans-Activators,
pubmed-meshheading:20829881-Transcription Factors,
pubmed-meshheading:20829881-Tumor Suppressor Protein p53,
pubmed-meshheading:20829881-Tumor Suppressor Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
SATB2 augments ?Np63? in head and neck squamous cell carcinoma.
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pubmed:affiliation |
Department of Molecular Genetics, University of Toronto, Cell Biology Program, Hospital for Sick Children Research Institute, Department of Paediatrics, 555 University Avenue, Toronto, Ontario, M5G 1L7, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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