Linked Life Data

20827716

Source:http://linkedlifedata.com/resource/pubmed/id/20827716

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-9-9
pubmed:abstractText
This unit describes a straightforward method for preparing glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers using standard cyanoethyl phosphoramidite chemistry. GNA is an unnatural nucleic acid analog composed of an acyclic three-carbon sugar-phosphate backbone that contains one stereogenic center per repeating unit. GNA has attracted significant attention as a nucleic acid derivative due to its unique ability to form stable Watson-Crick anti-parallel duplex structures with thermal and thermodynamic stabilities rivaling those of natural DNA and RNA. The chemical simplicity of this nucleic acid structure provides access to enantiomerically pure forms of right- and left-handed helical structures that can be used as unnatural building blocks in DNA nanotechnology.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1934-9289
pubmed:author
pubmed:copyrightInfo
(c) 2010 by John Wiley & Sons, Inc.
pubmed:issnType
Electronic
pubmed:volume
Chapter 4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
Unit4.40
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Synthesis of glycerol nucleic acid (GNA) phosphoramidite monomers and oligonucleotide polymers.
pubmed:affiliation
Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't