Linked Life Data

20827502

Source:http://linkedlifedata.com/resource/pubmed/id/20827502

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2011-5-16
pubmed:abstractText
Although resistance to change is a main feature of autism, the brain processes underlying this aspect of the disorder remain poorly understood. The aims of this study were to examine neural basis of auditory change-detection in children with autism spectrum disorders (ASD; N = 27) through electrophysiological patterns (MMN, P3a) and to test whether these are quantitatively related to intolerance of change (using the BSE-R scale). ASD displayed significantly shorter MMN latency and larger P3a than controls, indicating a greater tendency to switch attention to deviant events. These electrophysiological abnormalities were significantly more marked in children who displayed greater difficulties in tolerating change. The atypical neurophysiological mechanism of change perception identified might thus be associated with one of the hallmark behavioural manifestations of autism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1573-3432
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
705-14
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Candidate electrophysiological endophenotypes of hyper-reactivity to change in autism.
pubmed:affiliation
UMRS Imagerie et Cerveau, Inserm U930, CNRS FRE 2448, Université François Rabelais de Tours, CHRU, Tours, France. marie.gomot@univ-tours.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't