|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009079,
umls-concept:C0205245,
umls-concept:C0243076,
umls-concept:C0332120,
umls-concept:C0597357,
umls-concept:C0599278,
umls-concept:C0679932,
umls-concept:C0682972,
umls-concept:C1136161,
umls-concept:C1167622,
umls-concept:C1367690,
umls-concept:C1426330,
umls-concept:C1428424,
umls-concept:C1704675
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2010-11-16
|
|
pubmed:abstractText |
The h5-HT(7) receptor is subject to inactivation by risperidone and 9-OH-risperidone, apparently through a pseudo-irreversible complex formed between these drugs and the receptor. Although risperidone and 9-OH-risperidone ("inactivating antagonists") completely inactivate the receptor, only 50% of the receptors form a pseudo-irreversible complex with these drugs.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-10725388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-11130463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-11283750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-11583811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-14603306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-15504107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-15821958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-16195233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-16567090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-16857671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-16870886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-17011524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-17329545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-18022255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-18996971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-19116626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-19219011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-19509219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-19648932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-19897419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-20054398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-4202581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-8226867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-8394362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20827463-8398139
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/9-hydroxy-risperidone,
http://linkedlifedata.com/resource/pubmed/chemical/Clozapine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Isoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Subunits,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Risperidone,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 7 receptor
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
1432-2072
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
212
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
687-97
|
|
pubmed:dateRevised |
2011-7-26
|
|
pubmed:meshHeading |
pubmed-meshheading:20827463-Binding, Competitive,
pubmed-meshheading:20827463-Biosensing Techniques,
pubmed-meshheading:20827463-Cell Line,
pubmed-meshheading:20827463-Clozapine,
pubmed-meshheading:20827463-Cyclic AMP,
pubmed-meshheading:20827463-Dose-Response Relationship, Drug,
pubmed-meshheading:20827463-Humans,
pubmed-meshheading:20827463-Isoxazoles,
pubmed-meshheading:20827463-Protein Binding,
pubmed-meshheading:20827463-Protein Multimerization,
pubmed-meshheading:20827463-Protein Subunits,
pubmed-meshheading:20827463-Pyrimidines,
pubmed-meshheading:20827463-Radioligand Assay,
pubmed-meshheading:20827463-Receptors, Serotonin,
pubmed-meshheading:20827463-Risperidone,
pubmed-meshheading:20827463-Serotonin Antagonists,
pubmed-meshheading:20827463-Transfection
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions.
|
|
pubmed:affiliation |
Center for Neuropharmacology & Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA. teitlem@mail.amc.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
