Linked Life Data

2082713

Source:http://linkedlifedata.com/resource/pubmed/id/2082713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-5-7
pubmed:abstractText
A study was made on nerve conduction velocity of the optic nerve in rats subjected to lead exposure during the first 2 weeks of post-natal life. The rats were given intraperitoneal injections with a calculated daily exposure of 7.6 micrograms (low-dose) or 15.8 micrograms (high-dose) lead g-1 body weight. Growth retardation at 30 days was seen only with the higher dose. Littermates of low-dose exposed rat were injected with vehicle only and served as controls. Lead concentrations in blood and brain were measured in rats of 20 days of age in order to ascertain that exposure was adequate in the present litters. Nerve conduction velocity of the optic nerve was examined in 14 rats of 30 days of age taken from 10 different litters. The optic nerve(s) was prepared in anaesthetized rats and placed in a flow-through incubation chamber. One stimulating and two recording tungsten electrodes were used. In all rats, three positive-negative waves, regarded as representing three functional groups of optic nerve axons, could be recorded. The last one often had a long duration and a small amplitude without distinct peaks and hence was omitted from further analysis. The mean conduction velocities for the two faster axonal groups were 16.8 and 5.4 m s-1 in control rats, 10.3 and 5.8 m s-1 in low-dose rats and 9.4 and 5.2 m s-1 in high-dose rats. The difference in conduction velocity for the fastest axons was significant for controls versus low-dose and high-dose but not for low-dose versus high-dose.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
515-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Decreased nerve conduction velocity in optic nerve following early post-natal low-dose lead exposure.
pubmed:affiliation
Department of Pathology, University of Gothenburg, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't