Linked Life Data

20826914

Source:http://linkedlifedata.com/resource/pubmed/id/20826914

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-9-9
pubmed:abstractText
14-3-3 sigma (?) induces G2 arrest enabling the repair of damaged DNA. The function of 14-3-3 ? is frequently lost in tumor cells, indicating a potential tumor suppressor function. The purpose of this study was to evaluate the prognostic value of 14-3-3 ? expression in human gastric cancer. 14-3-3 ? expression was analyzed by immunohistochemistry in 157 tumor samples of patients, who underwent resection for gastric cancer. Since 14-3-3 ? is involved in the p53 network, p53 expression was detected in parallel and correlated with 14-3-3 ?. 14-3-3 ? was found to be overexpressed in 75 (47.8%) of 157 cases, the overexpression rate of p53 protein was 27.4%. 14-3-3 ? overexpression was statistically significantly associated with pT-stage (p=0.041) pN-stage (p=0.015) and UICC-stage (p=0.019) and showed a borderline significance with Lauren classification (p=0.057). Univariate survival calculations revealed a coexistent 14-3-3 ? and p53 overexpression as a significant predictor of disease-free survival. Multivariate analysis did not unfold 14-3-3 as an independent prognostic factor for disease-free survival and overall survival. Concomitant 14-3-3 ? and p53 overexpression in tumor cells of patients with gastric cancer identifies a population of patients with relatively unfavorable prognosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1875-8630
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-9
pubmed:dateRevised
2011-1-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
14-3-3 sigma and p53 expression in gastric cancer and its clinical applications.
pubmed:affiliation
Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Anichstrasse 35, Innsbruck, Austria. gilbert.muehlmann@imed.ac.at
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't