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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-9-9
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pubmed:abstractText |
The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with an increase in cardiovascular events.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-6744
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pubmed:author |
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pubmed:copyrightInfo |
2010 Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
160
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
506-12
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20826260-Aged,
pubmed-meshheading:20826260-Alleles,
pubmed-meshheading:20826260-Angioplasty, Balloon, Coronary,
pubmed-meshheading:20826260-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:20826260-Biotransformation,
pubmed-meshheading:20826260-Cardiovascular Diseases,
pubmed-meshheading:20826260-Coronary Angiography,
pubmed-meshheading:20826260-Coronary Restenosis,
pubmed-meshheading:20826260-Female,
pubmed-meshheading:20826260-Humans,
pubmed-meshheading:20826260-Male,
pubmed-meshheading:20826260-Middle Aged,
pubmed-meshheading:20826260-Multivariate Analysis,
pubmed-meshheading:20826260-Myocardial Infarction,
pubmed-meshheading:20826260-Platelet Aggregation Inhibitors,
pubmed-meshheading:20826260-Polymorphism, Genetic,
pubmed-meshheading:20826260-Recurrence,
pubmed-meshheading:20826260-Reoperation,
pubmed-meshheading:20826260-Stents,
pubmed-meshheading:20826260-Stroke,
pubmed-meshheading:20826260-Ticlopidine
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pubmed:year |
2010
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pubmed:articleTitle |
Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events.
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pubmed:affiliation |
Deutsches Herzzentrum München, Rechts der Isar, Technische Universität, Germany. klaustiroch@hotmail.com
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pubmed:publicationType |
Journal Article
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