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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-11-2
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pubmed:abstractText |
MicroRNAs (miRNAs) are members of a class of small noncoding functional RNAs that modulate gene regulation at the post-transcriptional level in a sequence specific manner. miRNA dysfunction has been linked to the pathophysiology of human diseases including those resulting from viral infections. The objective of this study was to investigate changes in miRNA profiles that occur in hepatoma cells expressing hepatitis C virus (HCV) and identify anticorrelated mRNAs, which may be their regulatory targets.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1478-3231
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pubmed:author |
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pubmed:copyrightInfo |
© 2010 John Wiley & Sons A/S.
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1490-504
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pubmed:meshHeading |
pubmed-meshheading:20825557-Algorithms,
pubmed-meshheading:20825557-Carcinoma, Hepatocellular,
pubmed-meshheading:20825557-Cell Line, Tumor,
pubmed-meshheading:20825557-Cluster Analysis,
pubmed-meshheading:20825557-Computational Biology,
pubmed-meshheading:20825557-Gene Expression Profiling,
pubmed-meshheading:20825557-Gene Expression Regulation,
pubmed-meshheading:20825557-Gene Regulatory Networks,
pubmed-meshheading:20825557-Hepacivirus,
pubmed-meshheading:20825557-Hepatitis C, Chronic,
pubmed-meshheading:20825557-Humans,
pubmed-meshheading:20825557-Liver Neoplasms,
pubmed-meshheading:20825557-MicroRNAs,
pubmed-meshheading:20825557-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20825557-RNA, Messenger,
pubmed-meshheading:20825557-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20825557-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Parallel microRNA and mRNA expression profiling of (genotype 1b) human hepatoma cells expressing hepatitis C virus.
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pubmed:affiliation |
The Laboratory for Liver Digestive and Metabolic Disorders, Liver Biliary and Pancreatic Center, Carolinas Medical Center, Cannon Research Center, Charlotte, NC 28203, USA. nury.steuerwald@carolinashealthcare.org
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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