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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-9-8
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pubmed:abstractText |
There are no drugs presently available to treat traumatic brain injury (TBI). A variety of single drugs have failed clinical trials suggesting a role for drug combinations. Drug combinations acting synergistically often provide the greatest combination of potency and safety. The drugs examined (minocycline (MINO), N-acetylcysteine (NAC), simvastatin, cyclosporine A, and progesterone) had FDA-approval for uses other than TBI and limited brain injury in experimental TBI models.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e12490
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pubmed:meshHeading |
pubmed-meshheading:20824218-Acetylcysteine,
pubmed-meshheading:20824218-Animals,
pubmed-meshheading:20824218-Avoidance Learning,
pubmed-meshheading:20824218-Brain Injuries,
pubmed-meshheading:20824218-Cognition,
pubmed-meshheading:20824218-Conditioning (Psychology),
pubmed-meshheading:20824218-Drug Synergism,
pubmed-meshheading:20824218-Interleukin-1beta,
pubmed-meshheading:20824218-Memory,
pubmed-meshheading:20824218-Minocycline,
pubmed-meshheading:20824218-Myelin Sheath,
pubmed-meshheading:20824218-Perception,
pubmed-meshheading:20824218-Rats,
pubmed-meshheading:20824218-Rats, Sprague-Dawley,
pubmed-meshheading:20824218-Task Performance and Analysis,
pubmed-meshheading:20824218-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Minocycline synergizes with N-acetylcysteine and improves cognition and memory following traumatic brain injury in rats.
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pubmed:affiliation |
Departments of Physiology and Pharmacology, State University of New York-Downstate Medical Center, Brooklyn, New York, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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