Source:http://linkedlifedata.com/resource/pubmed/id/20823448
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2010-11-30
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pubmed:abstractText |
The objective of this study was to assess the response of a large animal model to high dietary fat and fructose (HFFD). Three different metabolic assessments were performed during 13 wk of feeding an HFFD (n = 10) or chow control (CTR, n = 4) diet: oral glucose tolerance tests (OGTTs; baseline, 4 and 8 wk), hyperinsulinemic-euglycemic clamps (HIEGs; baseline and 10 wk) and hyperinsulinemic-hyperglycemic clamps (HIHGs, 13 wk). The ?AUC for glucose during the OGTTs more than doubled after 4 and 8 wk of HFFD feeding, and the average glucose infusion rate required to maintain euglycemia during the HIEG clamps decreased by ?30% after 10 wk of HFFD feeding. These changes did not occur in the CTR group. The HIHG clamps included experimental periods 1 (P1, 0-90 min) and 2 (P2, 90-180 min). During P1, somatostatin, basal intraportal glucagon, 4 × basal intraportal insulin, and peripheral glucose (to double the hepatic glucose load) were infused; during P2, glucose was also infused intraportally (4.0 mg·kg(-1)·min(-1)). Net hepatic glucose uptake during P1 and P2 was -0.4 ± 0.1 [output] and 0.2 ± 0.8 mg·kg(-1)·min(-1) in the HFFD group, respectively, and 1.8 ± 0.8 and 3.5 ± 1.0 mg·kg(-1)·min(-1) in the CTR group, respectively (P < 0.05 vs. HFFD during P1 and P2). Glycogen synthesis through the direct pathway was 0.5 ± 0.2 and 1.5 ± 0.4 mg·kg(-1)·min(-1) in the HFFD and CTR groups, respectively (P < 0.05 vs. HFFD). In conclusion, chronic consumption of an HFFD diminished the sensitivity of the liver to hormonal and glycemic cues and resulted in a marked impairment in NHGU and glycogen synthesis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Fructose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1522-1555
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
299
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
E887-98
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pubmed:dateRevised |
2011-2-14
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pubmed:meshHeading |
pubmed-meshheading:20823448-Analysis of Variance,
pubmed-meshheading:20823448-Animals,
pubmed-meshheading:20823448-Area Under Curve,
pubmed-meshheading:20823448-Biological Transport,
pubmed-meshheading:20823448-Dietary Carbohydrates,
pubmed-meshheading:20823448-Dietary Fats,
pubmed-meshheading:20823448-Dogs,
pubmed-meshheading:20823448-Fructose,
pubmed-meshheading:20823448-Glucagon,
pubmed-meshheading:20823448-Glucose,
pubmed-meshheading:20823448-Glucose Clamp Technique,
pubmed-meshheading:20823448-Glucose Intolerance,
pubmed-meshheading:20823448-Glucose Tolerance Test,
pubmed-meshheading:20823448-Liver,
pubmed-meshheading:20823448-Male
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pubmed:year |
2010
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pubmed:articleTitle |
Chronic consumption of a high-fat/high-fructose diet renders the liver incapable of net hepatic glucose uptake.
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pubmed:affiliation |
Vanderbilt Univ. School of Medicine, Nashville, TN 37232, USA. katie.colbert@vanderbilt.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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