rdf:type |
|
lifeskim:mentions |
umls-concept:C0010798,
umls-concept:C0030705,
umls-concept:C0055729,
umls-concept:C0070166,
umls-concept:C0522523,
umls-concept:C0871261,
umls-concept:C1522318,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1882417,
umls-concept:C1948041,
umls-concept:C2825951,
umls-concept:C2911692
|
pubmed:issue |
5
|
pubmed:dateCreated |
2010-10-20
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pubmed:databankReference |
|
pubmed:abstractText |
Among patients treated with clopidogrel, carriers of the cytochrome P450 (CYP) 2C19 loss-of-function allele have shown increased platelet reactivity and higher rates of ischemic events. Although adjunctive cilostazol to dual antiplatelet therapy (or "triple antiplatelet therapy") intensifies platelet inhibition, it remains unknown whether triple antiplatelet therapy after percutaneous coronary intervention can achieve adequate platelet inhibition in patients with the CYP2C19 mutant allele.
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pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Codon, Nonsense,
http://linkedlifedata.com/resource/pubmed/chemical/P2RY12 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P2Y12,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Ticlopidine,
http://linkedlifedata.com/resource/pubmed/chemical/cilostazol,
http://linkedlifedata.com/resource/pubmed/chemical/clopidogrel
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
pubmed:issn |
1941-7632
|
pubmed:author |
pubmed-author:HwangJin-YongJY,
pubmed-author:HwangSeok-JaeSJ,
pubmed-author:JeongYoung-HoonYH,
pubmed-author:KangMin-KyungMK,
pubmed-author:KimIn-SukIS,
pubmed-author:KimSunjooS,
pubmed-author:KohEun-HaEH,
pubmed-author:KohJin-SinJS,
pubmed-author:KwakChoong HwanCH,
pubmed-author:ParkJeong RangJR,
pubmed-author:ParkKi-SooKS,
pubmed-author:ParkYongwhiY
|
pubmed:issnType |
Electronic
|
pubmed:volume |
3
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
450-9
|
pubmed:meshHeading |
pubmed-meshheading:20823393-Adenosine Diphosphate,
pubmed-meshheading:20823393-Angioplasty, Balloon, Coronary,
pubmed-meshheading:20823393-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:20823393-Blood Platelets,
pubmed-meshheading:20823393-Chemotherapy, Adjuvant,
pubmed-meshheading:20823393-Codon, Nonsense,
pubmed-meshheading:20823393-DNA Mutational Analysis,
pubmed-meshheading:20823393-Humans,
pubmed-meshheading:20823393-Ischemia,
pubmed-meshheading:20823393-Platelet Aggregation,
pubmed-meshheading:20823393-Polymorphism, Genetic,
pubmed-meshheading:20823393-Receptors, Purinergic P2Y12,
pubmed-meshheading:20823393-Tetrazoles,
pubmed-meshheading:20823393-Ticlopidine
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pubmed:year |
2010
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pubmed:articleTitle |
Cytochrome 2C19 polymorphism and response to adjunctive cilostazol versus high maintenance-dose clopidogrel in patients undergoing percutaneous coronary intervention.
|
pubmed:affiliation |
Division of Cardiology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|