Source:http://linkedlifedata.com/resource/pubmed/id/20823096
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2010-11-15
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pubmed:abstractText |
SSc (scleroderma) is an often fatal disease characterized by widespread tissue fibrosis. Fibroblasts play a key role in SSc-associated fibrosis. This study was designed to determine: (i) whether fibroblasts isolated from skin of patients with SSc have increased lysophosphatidic acid-activated Cl- current (IClLPA) activity vs healthy controls; (ii) whether myofibroblast differentiation is involved in SSc skin fibrosis; and (iii) whether SSc fibroblasts have different proliferation rates vs controls.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1462-0332
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2290-7
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pubmed:meshHeading |
pubmed-meshheading:20823096-Actins,
pubmed-meshheading:20823096-Adult,
pubmed-meshheading:20823096-Analysis of Variance,
pubmed-meshheading:20823096-Case-Control Studies,
pubmed-meshheading:20823096-Cells, Cultured,
pubmed-meshheading:20823096-Chlorides,
pubmed-meshheading:20823096-Female,
pubmed-meshheading:20823096-Fibroblasts,
pubmed-meshheading:20823096-Humans,
pubmed-meshheading:20823096-Lysophospholipids,
pubmed-meshheading:20823096-Male,
pubmed-meshheading:20823096-Middle Aged,
pubmed-meshheading:20823096-Muscle, Smooth,
pubmed-meshheading:20823096-Myofibroblasts,
pubmed-meshheading:20823096-Scleroderma, Systemic,
pubmed-meshheading:20823096-Skin
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pubmed:year |
2010
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pubmed:articleTitle |
Lysophosphatidic acid-activated Cl- current activity in human systemic sclerosis skin fibroblasts.
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pubmed:affiliation |
Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave., Memphis, TN 38163, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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