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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17-18
pubmed:dateCreated
2010-11-15
pubmed:abstractText
Chemical examination of the stems and twigs of the mangrove plant Excoecaria agallocha L. resulted in the isolation of six ent-kaurane diterpenoids named agallochaols K-P (1-6), an atisane-type diterpenoid agallochaol Q (7), along with eight known diterpenoids (8-15). Their structures were elucidated on the basis of extensive spectroscopic analysis and by comparison of their NMR spectroscopic data with those reported in literature, in association with the biogenetic relationship with the X-ray structure of 9. Compounds 1, 5-7, 9-10, and 13 showed anti-inflammatory potency to suppress expression of NF-?B and AP-1 targeted genes including TNF-? and IL-6 induced by lipopolysaccharide (LPS) in mouse macrophages Raw 264.7 cells. In addition, compounds 1, 5-7, 9-10, and 13 block NF-?B activation, while compounds 1 and 7 block AP-1 activation dramatically, indicating these compounds possess an anti-inflammatory potential in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1873-3700
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2124-31
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
TNF-? inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L.
pubmed:affiliation
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China.
pubmed:publicationType
Journal Article