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pubmed:abstractText |
(-)-Spongidepsin 1, a cytotoxic marine natural product, was prepared via two iridium-catalyzed hydrogenation reactions; both were highly stereoselective, giving convenient access to pivotal intermediates. This synthesis was modified to give several spongidepsin analogues, and their cytotoxicities were compared with those of the natural product.
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pubmed:affiliation |
Texas A & M University, Chemistry Department, P.O. Box 30012, College Station, Texas 77842, USA.
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