Linked Life Data

2082201

Source:http://linkedlifedata.com/resource/pubmed/id/2082201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-5-9
pubmed:abstractText
Using the isolated perfused in situ rat adrenal preparation, we have shown a direct stimulatory action of calcitonin gene-related peptide on aldosterone secretion. The threshold dose for this action was 1 pmol, given as a bolus in 200 ul. CGRP also caused vasodilation in the adrenal gland, reflected in increased perfusate flow, and also stimulated corticosterone secretion, with a threshold of 0.1 pmol. Addition of CGRP to incubations of collagenase-dispersed adrenocortical cells had no effect on steroidogenesis. These results support the contention that CGRP, which have been identified in nerve terminals in the zona glomerulosa of the rat adrenal cortex, may have a role in the control of steroid secretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0143-4179
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Calcitonin gene-related peptide stimulates adrenocortical function in the isolated perfused rat adrenal gland in situ.
pubmed:affiliation
Department of Biochemistry, St Bartholomew's Hospital Medical College, London, UK.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't