Source:http://linkedlifedata.com/resource/pubmed/id/20821730
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2010-11-1
|
| pubmed:abstractText |
For homeostasis, T cells integrate non-cognate TCR-dependent and -independent signals to survive and weakly proliferate. In contrast to antigen-specific, stable, and long-lived contacts, signaling in short-lived homeostatic interactions depends upon the coordination of ongoing T-cell migration on the surface of DC and signaling at the cell-cell junction. To mimic peripheral tissues and analyze how T-cell migration and cell-cell signaling are integrated, we used live-cell imaging and 3-D reconstruction of fixed conjugates between DO11.10 T cells and DC in 3-D low-density collagen matrices. T cells simultaneously maintained amoeboid migration and polarized towards the DC, leading to a fully dynamic interaction plane that delivered signals for homeostatic T-cell survival and proliferation. The contact plane comprised three zones, the actin-rich leading edge poor in signal but driving migration, a mid-zone mediating TCR/MHC-induced signal associated with proliferation, and the rear uropod mediating predominantly MHC-independent signals. Thus a dynamic immunological synapse with distinct signaling sectors enables moving T cells to serially sample resident tissue cells and acquire molecular information "en passant".
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Function-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1521-4141
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2741-50
|
| pubmed:meshHeading |
pubmed-meshheading:20821730-Animals,
pubmed-meshheading:20821730-Antigens, CD3,
pubmed-meshheading:20821730-Cell Communication,
pubmed-meshheading:20821730-Cell Movement,
pubmed-meshheading:20821730-Cell Polarity,
pubmed-meshheading:20821730-Collagen,
pubmed-meshheading:20821730-Dendritic Cells,
pubmed-meshheading:20821730-Histocompatibility Antigens,
pubmed-meshheading:20821730-Homeostasis,
pubmed-meshheading:20821730-Imaging, Three-Dimensional,
pubmed-meshheading:20821730-Lymphocyte Function-Associated Antigen-1,
pubmed-meshheading:20821730-Mice,
pubmed-meshheading:20821730-Mice, Inbred BALB C,
pubmed-meshheading:20821730-Mice, Knockout,
pubmed-meshheading:20821730-Microscopy, Confocal,
pubmed-meshheading:20821730-Phosphotyrosine,
pubmed-meshheading:20821730-Receptors, Antigen, T-Cell,
pubmed-meshheading:20821730-Signal Transduction,
pubmed-meshheading:20821730-T-Lymphocytes
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
A dynamic immunological synapse mediates homeostatic TCR-dependent and -independent signaling.
|
| pubmed:affiliation |
Department of Dermatology and Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|