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pubmed-article:20821329pubmed:abstractText5-Fluorouracil remains widely used in colorectal cancer treatment more than 40 years after its development. 19F magnetic resonance spectroscopy can be used in vivo to measure 5FU's half-life and metabolism to cytotoxic fluoronucleotides. Previous studies have shown better survival associated with longer 5FU tumour half-life. This work investigated 5FU pharmacokinetics in liver metastases of colorectal cancer.lld:pubmed
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pubmed-article:20821329pubmed:articleTitleCan localised (19)F magnetic resonance spectroscopy pharmacokinetics of 5FU in colorectal metastases predict clinical response?lld:pubmed
pubmed-article:20821329pubmed:affiliationCancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, UK. dominick.mcintyre@cancer.org.uklld:pubmed
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