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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-11-15
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pubmed:abstractText |
SSc is an autoimmune disease characterized by fibrosis of the skin and internal organs. Although the aetiology remains uncertain, many reports have suggested that IL-6 is involved in SSc pathogenesis. Tocilizumab, an anti-IL-6 receptor antibody, is an anti-arthritis medicine that works through the blockade of IL-6 functions. To examine the effect of tocilizumab on SSc, we administered tocilizumab to two SSc patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antirheumatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/tocilizumab
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1462-0332
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pubmed:author |
pubmed-author:ArimitsuJunsukeJ,
pubmed-author:HagiharaKeisukeK,
pubmed-author:HiranoToruT,
pubmed-author:KatayamaIchiroI,
pubmed-author:KawaiMariM,
pubmed-author:KawaseIchiroI,
pubmed-author:KishimotoTadamitsuT,
pubmed-author:KitabaShunS,
pubmed-author:KuwaharaYusukeY,
pubmed-author:MurotaHiroyukiH,
pubmed-author:NarazakiMasashiM,
pubmed-author:OgataAtsushiA,
pubmed-author:ShimaYoshihitoY,
pubmed-author:TanakaToshioT
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pubmed:issnType |
Electronic
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2408-12
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20819796-Adult,
pubmed-meshheading:20819796-Antibodies, Anti-Idiotypic,
pubmed-meshheading:20819796-Antibodies, Monoclonal,
pubmed-meshheading:20819796-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:20819796-Antirheumatic Agents,
pubmed-meshheading:20819796-Female,
pubmed-meshheading:20819796-Humans,
pubmed-meshheading:20819796-Male,
pubmed-meshheading:20819796-Middle Aged,
pubmed-meshheading:20819796-Receptors, Interleukin-6,
pubmed-meshheading:20819796-Scleroderma, Systemic,
pubmed-meshheading:20819796-Severity of Illness Index,
pubmed-meshheading:20819796-Skin
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pubmed:year |
2010
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pubmed:articleTitle |
The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab.
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pubmed:affiliation |
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. ryanjin@imed3.med.osaka-u.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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