|
rdf:type |
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lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0017262,
umls-concept:C0033414,
umls-concept:C0034693,
umls-concept:C0174680,
umls-concept:C0185117,
umls-concept:C0239059,
umls-concept:C0458827,
umls-concept:C1135918,
umls-concept:C1514485,
umls-concept:C1555707,
umls-concept:C1705851,
umls-concept:C1998811,
umls-concept:C2752151,
umls-concept:C2828366,
umls-concept:C2911684
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pubmed:issue |
13
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pubmed:dateCreated |
2010-9-7
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pubmed:abstractText |
Increased proliferation of airway smooth muscle cells (ASMCs) are observed in asthmatic patients and smoking can accelerate proliferation of ASMCs in asthma. To elucidate the molecular mechanisms leading to these changes, we studied in vitro the effect of cigarette smoke extract (CSE) on the proliferation of ASMCs and the expression of cyclin D1, an important regulatory protein implicated in cell cycle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0366-6999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
123
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1709-14
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pubmed:meshHeading |
pubmed-meshheading:20819634-Animals,
pubmed-meshheading:20819634-Asthma,
pubmed-meshheading:20819634-Blotting, Western,
pubmed-meshheading:20819634-Cell Cycle,
pubmed-meshheading:20819634-Cell Proliferation,
pubmed-meshheading:20819634-Cells, Cultured,
pubmed-meshheading:20819634-Cyclin D1,
pubmed-meshheading:20819634-Disease Models, Animal,
pubmed-meshheading:20819634-Female,
pubmed-meshheading:20819634-Flow Cytometry,
pubmed-meshheading:20819634-Immunohistochemistry,
pubmed-meshheading:20819634-Microscopy, Phase-Contrast,
pubmed-meshheading:20819634-Myocytes, Smooth Muscle,
pubmed-meshheading:20819634-Plant Extracts,
pubmed-meshheading:20819634-Rats,
pubmed-meshheading:20819634-Respiratory System,
pubmed-meshheading:20819634-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20819634-Smoking,
pubmed-meshheading:20819634-Tobacco
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pubmed:year |
2010
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pubmed:articleTitle |
Cigarette smoke extract promotes proliferation of airway smooth muscle cells in asthmatic rats via regulating cyclin D1 expression.
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pubmed:affiliation |
Department of Respiratory Medicine, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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