Linked Life Data

20818803

Source:http://linkedlifedata.com/resource/pubmed/id/20818803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-10-8
pubmed:abstractText
In this article, we describe the characteristic (15)N chemical shifts of isatin oxime ethers and their isomer nitrone. These oxime ethers and nitrones are the alkylation reaction products of isatin oximes. In our study, the (15)N chemical shifts observed in these oxime ethers were in the 402-408 (or 22-28) ppm range, although those for their corresponding nitrone series were in the 280-320 (or -100 to -60) ppm range. This remarkable difference in (15)N NMR chemical shift values could potentially be used to determine the O- versus N-alkylation of oximes, even when only one isomer is available. In this paper, the differences in (15)N NMR chemical shifts serve as the basis for a discussion about how to distinguish both regioisomers derived from the oximes alkylation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1097-458X
pubmed:author
pubmed:copyrightInfo
2010 John Wiley & Sons, Ltd.
pubmed:issnType
Electronic
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
873-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
15N chemical shifts of a series of isatin oxime ethers and their corresponding nitrone isomers.
pubmed:affiliation
Department of Drug Metabolism, Covance Company, 3301 Kinsman Boulevard, Madison, WI 53704, USA.
pubmed:publicationType
Journal Article