Linked Life Data

20818147

Source:http://linkedlifedata.com/resource/pubmed/id/20818147

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-9-6
pubmed:abstractText
CD69 is a type II membrane protein expressed as a homodimer composed of heavily glycosylated subunits. CD69 is known as an early activation marker antigen of lymphocytes,and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. In order to address the role of CD69 in the pathogenesis of arthritis and allergic airway inflammation, we established CD69-deficient mice. CD69-deficient mice displayed a markedly attenuated arthritic inflammatory response and airway inflammation. The administration of anti-CD69 antibody inhibited the induction of the antigen-induced airway inflammation and hyperresponsiveness. These results indicate that CD69 plays a crucial role in the pathogenesis of arthritis and allergic airway inflammation and that CD69 could be a possible therapeutic target for arthritis and asthma in human patients.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1349-7413
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-95
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
[Role of CD69 in the pathogenesis of inflammation].
pubmed:affiliation
Department of Microbiology and Immunology, Graduate School of Medicine, Yamaguchi University.
pubmed:publicationType
Journal Article, English Abstract, Review