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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-10-19
pubmed:abstractText
Inter- and intragenic noncoding transcription is widespread in eukaryotic genomes; however, the purpose of these types of transcription is still poorly understood. Here, we show that intragenic sense-oriented transcription within the budding yeast ASP3 coding region regulates a constitutively and immediately accessible promoter for the transcription of full-length ASP3. Expression of this short intragenic transcript is independent of GATA transcription factors, which are essential for the activation of full-length ASP3, and independent of RNA polymerase II (RNAPII). Furthermore, we found that an intragenic control element is required for the expression of this noncoding RNA (ncRNA). Continuous expression of the short ncRNA maintains a high level of trimethylation of histone H3 at lysine 4 (H3K4me3) at the ASP3 promoter and makes this region more accessible for RNAPII to transcribe the full-length ASP3. Our results show for the first time that intragenic noncoding transcription promotes gene expression.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-10407276, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-10604478, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-10611304, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-10617575, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-10638745, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-10940301, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-11018013, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-11413190, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-11988577, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-12353038, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-12489124, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-12600945, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-12640466, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-12667453, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-12672492, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-12764140, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-14585615, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-14636589, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-15175754, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-15790807, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-16420678, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-16484372, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-16940175, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-17110333, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-17139254, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-17237763, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-17470801, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-17604720, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-17916692, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-18007593, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-18022365, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-18157120, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-18316478, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-18509338, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-18951091, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-18988810, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-19026778, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-19061643, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-19108609, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-19169244, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-19532144, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-19571181, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-20066094, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-2892826, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-3042786, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-3299050, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-3313277, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-342521, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-3537713, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-6152012, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-6264467, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-6995441, http://linkedlifedata.com/resource/pubmed/commentcorrection/20817754-7568152
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1469-9001
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2085-93
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Intragenic transcription of a noncoding RNA modulates expression of ASP3 in budding yeast.
pubmed:affiliation
Department of Microbiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan.
pubmed:publicationType
Journal Article
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